Antifungal combinations against Candida albicans biofilms in vitro.

نویسندگان

  • Stefano P Bachmann
  • Gordon Ramage
  • Kacy VandeWalle
  • Thomas F Patterson
  • Brian L Wickes
  • José L López-Ribot
چکیده

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 11  شماره 

صفحات  -

تاریخ انتشار 2003